Antagonistic interactions drive laguna 3hp dust collector host-virus evolutionary arms races, which often manifest as recurrent amino acid changes (i.e., positive selection) at their protein-protein interaction interfaces.Here, we investigated whether combinatorial mutagenesis of positions under positive selection in a host antiviral protein could
Understanding the mechanisms of cancer therapeutic resistance is fundamental to improving cancer care.There is clear benefit from chemotherapy in different breast cancer settings; however, knowledge of the mutations and genes that mediate resistance is incomplete.In this study, by modeling chemoresistance in patient-derived xenografts (PDXs), we sh
Insects are equipped with various types of antennal sensilla, which house thermosensitive neurons adapted to receive different parameters of the turbo air m3f24-1-n thermal environment for a variety of temperature-guided behaviors.In the leaf-cutting ant Atta vollenweideri, the physiology and the morphology of the thermosensitive sensillum coelocon
A flare-up of coronavirus disease 2019 (COVID-19) caused by the 2019 novel coronavirus (severe acute respiratory syndrome coronavirus-2 [SARS-CoV-2]) started in the city of Wuhan in China and is viewed as another strain that has not been distinguished earlier in people.SARS-COV-2 dominatingly causes sickness that ranges from the basic virus to beer
Photorhabdus insect-related toxins A and B (PirA and PirB) were first recognized as insecticidal toxins from Photorhabdus luminescens.However, subsequent studies showed that their homologs from Vibrio parahaemolyticus also play critical roles in the pathogenesis of acute hepatopancreatic necrosis disease (AHPND) in shrimps.Based on the structural f